Minireviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hypertens. Feb 23, 2016; 6(1): 36-40
Published online Feb 23, 2016. doi: 10.5494/wjh.v6.i1.36
Place of baroreceptor activation therapy in the treatment of resistant hypertension
Gian Paolo Rossi, Matteo Azzolini
Gian Paolo Rossi, Matteo Azzolini, Clinica dell’Ipertensione Arteriosa, Department of Medicine-DIMED, University of Padua, 35126 Padua, Italy
Author contributions: Rossi GP wrote the paper; Azzolini M performed the collected the data.
Supported by FORICA (The Foundation for Advanced Research in Hypertension and Cardiovascular diseases); the University of Padua (to GPR); HORIZON 2020; and COST-ADMIRE.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gian Paolo Rossi, MD, FACC, FAHA, Professor, Clinica dell’Ipertensione Arteriosa, Department of Medicine-DIMED, University of Padua, Via Giustiniani 2, 35126 Padova, Italy. gianpaolo.rossi@unipd.it
Telephone: +39-049-8212279 Fax: +39-049-8217873
Received: September 1, 2015
Peer-review started: September 8, 2015
First decision: September 29, 2015
Revised: October 7, 2015
Accepted: December 9, 2015
Article in press: December 10, 2015
Published online: February 23, 2016
Abstract

This mini review describes the development of the therapeutic concept of baroreceptor stimulation over the last fifty years alongside the more recent introduction of it for the treatment of drug - resistant hypertension. The pros and cons of this strategy of treatment over renal sympathetic denervation are also discussed in the light of the results of the studies done in the last decade.

Keywords: Resistant hypertension, Treatment, Baroreceptor stimulation, Renal denervation

Core tip: We herein describe the development of the therapeutic concept of baroreceptor stimulation for the treatment of drug-resistant hypertension. The ups and downs of this treatment strategy are discussed in the light of the results of the studies done in the last decade.