Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Feb 20, 2017; 7(1): 11-24
Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.11
Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis
Pedro Xavier-Elsas, Daniela Masid-de-Brito, Bruno Marques Vieira, Maria Ignez C Gaspar-Elsas
Pedro Xavier-Elsas, Daniela Masid-de-Brito, Department Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil
Bruno Marques Vieira, Maria Ignez C Gaspar-Elsas, Department Pediatrics, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, FIOCRUZ, Rio de Janeiro 22250-020, Brazil
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The authors declare no conflicting interests exist related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pedro Xavier-Elsas, MD, PhD, Associate Professor, Department Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Bloco I, Room I-2-066, Rio de Janeiro 21941-590, Brazil. pxelsas@micro.ufrj.br
Telephone: +55-21-996360108
Received: September 13, 2016
Peer-review started: September 14, 2016
First decision: October 21, 2016
Revised: November 1, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: February 20, 2017
Core Tip

Core tip: The bone-marrow is exquisitely sensitive to regulation by systemic events, which selectively increase production of different blood cell types to meet transient increases in demand following injury. An association between stress and allergy has long been known, but its mechanisms remain incompletely understood. The exploration of underlying mechanisms in a variety of murine models yielded evidence of separate but interrelated roles for adrenal glucocorticoid hormones and cysteinyl-leukotrienes in coupling systemic events to bone-marrow responses in vivo. We here discuss how these unlikely partners work together to promote eosinophilia but through subtle mechanisms also limit its magnitude.