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World J Exp Med. Sep 20, 2025; 15(3): 106677
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.106677
Fibrinogen superfamily proteins: Key regulators in hepatic disorders
Rong-Hui Qu, Yi Rong, Wen-Zhe Ni, Xing-Lin Huang, Yi-Zhuo Chen, Hai-Fang Li
Rong-Hui Qu, Yi Rong, Wen-Zhe Ni, Xing-Lin Huang, Yi-Zhuo Chen, Hai-Fang Li, College of Life Sciences, Shandong Agricultural University, Tai’an 271018, Shandong Province, China
Co-first authors: Rong-Hui Qu and Yi Rong.
Author contributions: Qu RH and Rong Y revised the manuscript, and they contributed equally to this article as co-first authors; Qu RH, Rong Y, Ni WZ, Huang XL, and Chen YZ wrote the original draft; Li HF supervised, conceived, verified, reviewed, and edited the manuscript; All authors were involved in the critical review of the results and have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Fang Li, Associate Professor, College of Life Sciences, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, Shandong Province, China. haifangli@sdau.edu.cn
Received: March 4, 2025
Revised: April 18, 2025
Accepted: June 20, 2025
Published online: September 20, 2025
Processing time: 161 Days and 6.3 Hours
Core Tip

Core Tip: In this article, we introduce three fibrinogen superfamily proteins: Fibrinogen, FG-like protein 1, and FG-like protein 2. We focus on their roles in liver injury, metabolic associated fatty liver disease, and hepatocellular carcinoma, as well as potential therapeutic approaches. This review aims to deepen the understanding of the relationship between the fibrinogen superfamily and liver diseases, providing new insights for the treatment of hepatic disorders.