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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Sep 20, 2025; 15(3): 106429
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.106429
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.106429
Systematic review and risk factor analysis of post-vitrectomy silicone oil migration to the central nervous system
Lucy Wing Wong, Division of Undergraduate, Chinese University of Hong Kong, Hong Kong 999077, China
Wai Yan Lam, Department of Ophthalmology, Grantham Hospital, Hong Kong 999077, China
Sunny Chi Lik Au, Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong 999077, China
Co-first authors: Lucy Wing Wong and Wai Yan Lam.
Author contributions: Wong LW drafted the manuscript; Wong LW and Lam WY analyzed the data; Wong LW and Au SCL acquired the data; Lam WY revised the manuscript; Au SCL designed the research study; all authors had full access to the data, contributed to the study, read and approved the final version for publication.
Conflict-of-interest statement: All authors have disclosed no conflicts of interest. This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sunny Chi Lik Au, Chief Physician, Research Fellow, Department of Ophthalmology, Tung Wah Eastern Hospital, 9/F, MO Office, Lo Ka Chow Memorial Ophthalmic Centre, No. 19 Eastern Hospital Road, Causeway Bay, Hong Kong 999077, China. kilihcua@gmail.com
Received: February 26, 2025
Revised: March 20, 2025
Accepted: April 7, 2025
Published online: September 20, 2025
Processing time: 167 Days and 18.2 Hours
Revised: March 20, 2025
Accepted: April 7, 2025
Published online: September 20, 2025
Processing time: 167 Days and 18.2 Hours
Core Tip
Core Tip: It is interesting to note that silicone oil (SiO) migration to optic chiasm causes visual field loss or deteriorated visual acuity in the contralateral eye. And timely treatment can reverse such complications. Cerebral ventricular migration (CVM) of SiO are largely asymptomatic, commonly being diagnosed on imaging for other medical issues. Most treatments are mainly conservative, especially as when it is asymptomatic. However, CVM was occasionally misrecognized as intraventricular haemorrhage. Healthcare providers should pay attention to this rare but possible event as this misidentification could potentially delay emergency treatments in stroke patients.