Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 30, 2020; 10(2): 10-25
Published online Mar 30, 2020. doi: 10.5493/wjem.v10.i2.10
Published online Mar 30, 2020. doi: 10.5493/wjem.v10.i2.10
Neutron-activated biodegradable samarium-153 acetylacetonate-poly-L-lactic acid microspheres for intraarterial radioembolization of hepatic tumors
Yin-How Wong, Basri Johan Jeet Abdullah, Rajendra Udyavara Acharya, Chai-Hong Yeong, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, Selangor, Malaysia
Hun-Yee Tan, School of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, Selangor, Malaysia
Azahari Kasbollah, Medical Technology Division, Malaysian Nuclear Agency, Bangi 43000, Selangor, Malaysia
Rajendra Udyavara Acharya, Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore 599489, Singapore
Author contributions: Wong YH performed the majority of experiments and analyzed the data; Tan HY assisted the physicochemical and radiolabeling tests; Kasbollah A organized and supervised the neutron activation process; Abdullah BJJ, Acharya RU and Yeong CH designed and coordinated the research; Wong YH and Yeong CH wrote the paper.
Supported by Fundamental Research Grant Scheme sanctioned by the Ministry of Education , Malaysia, No. FRGS/1/2019/SKK06/TAYLOR/02/3 .
Institutional review board statement: Not applicable
Institutional animal care and use committee statement: Not applicable.
Conflict-of-interest statement: The authors declared no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rajendra Udyavara Acharya, PhD, Professor, DEng, Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 535 Clementi Road, Singapore 599489, Singapore. aru@np.edu.sg
Received: October 20, 2019
Peer-review started: October 20, 2019
First decision: December 17, 2019
Revised: February 14, 2020
Accepted: March 1, 2020
Article in press: March 1, 2020
Published online: March 30, 2020
Peer-review started: October 20, 2019
First decision: December 17, 2019
Revised: February 14, 2020
Accepted: March 1, 2020
Article in press: March 1, 2020
Published online: March 30, 2020
Core Tip
Core tip: We developed and tested a neutron-activated, biodegradable samarium-153 acetylacetonate-poly-L-lactic acid microspheres formulation for radioembolization of hepatic tumors. The formulation is potentially useful for intraarterial hepatic radioembolization as an alternative to yttrium-90 microspheres due to their biodegradability, favorable physicochemical characteristics and excellent radionuclide retention efficiency. The synthesis of the formulation does not involve ionizing radiation and hence reducing the complication and cost of production.