Retrospective Cohort Study
Copyright ©The Author(s) 2020 Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 19, 2020; 9(2): 29-43
Published online Sep 19, 2020. doi: 10.5409/wjcp.v9.i2.29
Gastroesophageal reflux disease in pediatric esophageal atresia: Assessment of clinical symptoms and pH-impedance data
Marina Aksionchyk, Kirill Marakhouski, Aliaksandr Svirsky
Marina Aksionchyk, Department of Pediatric Gastroenterology, Diagnostic Division, Republican Scientific and Practical Center for Pediatric Surgery, Minsk 220013, Belarus
Kirill Marakhouski, Department of Endoscopy, Republican Scientific and Practical Center of Pediatric Surgery, Minsk 220013, Belarus
Aliaksandr Svirsky, Department of Pediatric surgery, Republican Scientific and Practical Center of Pediatric Surgery, Minsk 220013, Belarus
Author contributions: Aksionchyk M performed the pH-impedance testing and contributed to collection, analysis and interpretation of the patient’s clinical data, final diagnosis, and conception, drafting and revision of the manuscript for important intellectual content; Marakhouski K performed the upper gastrointestinal endoscopy, collection and analysis of the literature data, and statistical analyses, and contributed to conception, drafting and revision of the manuscript for important intellectual content; Svirsky A contributed to the acquisition and analysis of data, design of the work, and drafting and revision of the paper for important intellectual content; All authors gave final approval of the version to be published.
Institutional review board statement: The study was reviewed and approved by The National Centre of Pediatric Surgery at Minsk, Belarus, No. 24.08.2017.
Informed consent statement: All study participants and their legal guardian provided informed written consent prior to study participation, No. 37.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement–checklist of items, and the manuscript was prepared and revised according to the STROBE Statement–checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Marina Aksionchyk, MD, Doctor, Research Scientist, Department of Pediatric Gastroenterology, Diagnostic Division, Republican Scientific and Practical Center for Pediatric Surgery, Nezavisimosti Ave 64A, Minsk 220013, Belarus. marinaaksionchyk@dhc.by
Received: May 28, 2020
Peer-review started: May 28, 2020
First decision: June 15, 2020
Revised: June 28, 2020
Accepted: September 1, 2020
Article in press: September 1, 2020
Published online: September 19, 2020
Core Tip

Core Tip: Esophageal atresia (EA) is the most common congenital anomaly of the gastrointestinal tract. Gastroesophageal reflux disease (GERD) is a frequent and lifelong problem after EA repair. pH-impedance testing makes assessment of pH and other parameters of GERD possible, aiding disease diagnosis and management. Even asymptomatic patients should undergo monitoring of GERD to confirm the absence or the persistence of reflux, and the need to continue treatment. We analyzed data of children with EA open surgical repair to determine the features of GERD among them and propose some important issues for consideration in the follow-up program for these patients.