Brief Article
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World J Clin Pediatr. Feb 8, 2014; 3(1): 6-13
Published online Feb 8, 2014. doi: 10.5409/wjcp.v3.i1.6
Evaluation of oxidant-antioxidant status in overweight and morbidly obese Saudi children
Waleed H Albuali
Waleed H Albuali, Pediatric Department, College of Medicine, Dammam University, Dammam 31412, Kingdom of Saudi Arabia
Author contributions: Albuali WH solely contributed to this paper.
Correspondence to: Waleed H Albuali, MD, Assistant Professor of Paediatrics, Pediatric Department, College of Medicine, Dammam University, Dammam 31412, Pox Box 380, Al-Hsa 31982, Kingdom of Saudi Arabia.
Telephone: +966-13-5800820 Fax: +966-13-5800820
Received: June 23, 2013
Revised: January 7, 2014
Accepted: January 17, 2014
Published online: February 8, 2014
Core Tip

Core tip: Childhood obesity is growing at an alarming rate and is concomitant with an increasing prevalence of oxidative stress. The association between obesity and oxidative stress is illustrated in the present study that showed that obese children with body mass index greater than 35 kg/m2 had higher oxidative products, e.g., malondialdehyde, advanced oxidation protein products and oxidized low-density lipoprotein concentrations with lower antioxidants, e.g., superoxide dismutase, catalase, glutathione peroxidase (GSH-Px) and glutathione reductase, and GSH. Therefore, the early recognition of these changes in oxidant status in children is important for preventing the long-term complications of obesity and targeting individual subjects who are particularly at risk. In addition, improving the oxidant status in overweight and obese children may reduce obesity-related comorbidities in adulthood.