Minireview of the clinical efficacy of platelet-rich plasma, platelet-rich fibrin and blood-clot revascularization for the regeneration of immature permanent teeth

Table 1 Meta-analysis data of blood clot revascularization, platelet-rich plasma and platelet-rich fibrin for the regenerative endodontic treatment of immature teeth following trauma a one year follow-up

Article	Procedure (PRP, PRF or BCR)?	Apical closure?	Periapical lesion healing response	Root lengthening	Dentinal wall thickening
Jadhav et al[20], 2013	PRP	3/3 (100%) Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)
Jadhav et al[20], 2013	BCR	3/3 (100%) (Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)	3/3 (100%) (Satisfactory, good and excellent)
Alagl et al[21], 2017	PRP	14/15 (93.3%) (Complete closure)	15/15 (100%) (All lesions healed)	NA	NA
Alagl A et al[21], 2017	BCR	8/15 (53.3%) (Complete closure)	15/15 (100%) (All lesions healed)	NA	NA
Shivashankar et al[19], 2017	PRF	16/20 (80%) (Apical foramen response vs no response)	NA	13/20 (65%)	NA
Shivashankar et al[19], 2017	BCR	14/15 (93.3%) (Apical foramen response vs no response)	NA	13/15 (86.7%)	NA
Shivashankar et al[19], 2017	PRP	16/19 (84.2%) (Apical foramen response vs no response)	NA	12/19 (73.70%)	NA
Mean for all publications	PRF	16/20 (80%)	18/18 (100%)	13/20 (65%)	NA
Mean for all publications	BCR	25/33 (75.6%)	18/18 (100%)	16/18 (88.90%)	3/3 (100%)
Mean for all publications	PRP	33/37 (89.2%)	NA	15/22 (68.20%)	3/3 (100%)

BCR: Blood clot revascularization; PRF: Platelet-rich fibrin; PRP: Platelet-rich plasma.