Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stomatol. Jun 28, 2018; 6(1): 1-5
Published online Jun 28, 2018. doi: 10.5321/wjs.v6.i1.1
Minireview of the clinical efficacy of platelet-rich plasma, platelet-rich fibrin and blood-clot revascularization for the regeneration of immature permanent teeth
Peter E Murray
Peter E Murray, Department of Endodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, United States
Author contributions: Murray PE performed all the tasks described in this manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Peter E Murray, Professor, BSc, PhD, Department of Endodontics, College of Dental Medicine, Nova Southeastern University, 3200 S University Dr., Fort Lauderdale, FL 33328, United States.
Telephone: +1-954-2621743 Fax: +1-954-2621782
Received: February 6, 2018
Peer-review started: February 6, 2018
First decision: May 24, 2018
Revised: May 30, 2018
Accepted: June 14, 2018
Article in press: June 14, 2018
Published online: June 28, 2018
Core Tip

Core tip: The fractured or decayed immature permanent teeth of children and young adults aged 6 years to 28 which have a restorable crown, but thin dentinal walls may be regenerated by using a revascularization procedure which draws blood and stem cells into a disinfected root canal space. This study has shown that in addition to the most common method of using a blood clot revascularization technique, a platelet-rich plasma and a platelet-rich fibrin technique may also be used as alternatives.