Minireviews
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stomatol. Jun 28, 2018; 6(1): 1-5
Published online Jun 28, 2018. doi: 10.5321/wjs.v6.i1.1
Minireview of the clinical efficacy of platelet-rich plasma, platelet-rich fibrin and blood-clot revascularization for the regeneration of immature permanent teeth
Peter E Murray
Peter E Murray, Department of Endodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, United States
Author contributions: Murray PE performed all the tasks described in this manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Peter E Murray, Professor, BSc, PhD, Department of Endodontics, College of Dental Medicine, Nova Southeastern University, 3200 S University Dr., Fort Lauderdale, FL 33328, United States. petemurr@nova.edu
Telephone: +1-954-2621743 Fax: +1-954-2621782
Received: February 6, 2018
Peer-review started: February 6, 2018
First decision: May 24, 2018
Revised: May 30, 2018
Accepted: June 14, 2018
Article in press: June 14, 2018
Published online: June 28, 2018
Abstract

The aim of this mini-review was to investigate and compare the clinical efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), vs blood clot revascularization (BCR) for the regeneration of immature permanent teeth. The clinical efficacy of PRP, PRF, and BCR to regenerate 90 immature permanent teeth after one year, were compared for their ability to accomplish apical closure, a periapical lesion healing response, root lengthening, and dentinal wall thickening. The 90 cases were published in three different articles. The mean success rate for apical closure after one year was: PRP (89.2%) PRF (80%), and BCR (75.6%). The mean success rate for root lengthening after one year was: BCR (88.9%), PRP (68.2%), and PRF (65%). The periapical lesion healing response was 100% for BCR and 100% for PRP. Dentinal wall thickening was 100% for BCR, and 100% for PRP. All the PRP, PRF, and BCR treatments appeared to be effective. The published clinical results for PRP, PRF, and BCR indicate that these treatments are effective for the regeneration of immature permanent teeth.

Keywords: Saving immature teeth, Regenerative endodontics, Dental pulp, Revascularization, Apical closure

Core tip: The fractured or decayed immature permanent teeth of children and young adults aged 6 years to 28 which have a restorable crown, but thin dentinal walls may be regenerated by using a revascularization procedure which draws blood and stem cells into a disinfected root canal space. This study has shown that in addition to the most common method of using a blood clot revascularization technique, a platelet-rich plasma and a platelet-rich fibrin technique may also be used as alternatives.