Published online Aug 28, 2013. doi: 10.5319/wjo.v3.i3.58
Revised: July 10, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Core tip: Noise-induced hearing loss (NIHL) affects millions of people worldwide irrespective of age, sex, and race. Hearing aids and cochlear implants are currently the only available interventions. This review article summarizes the cellular and molecular mechanisms of NIHL to-date. Significant milestones in uncovering genetic predisposition to NIHL in humans, experimental gene therapies and post-noise otoprotective strategies to reduce the impact of NIHL are reviewed.