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World J Otorhinolaryngol. Aug 28, 2013; 3(3): 100-107
Published online Aug 28, 2013. doi: 10.5319/wjo.v3.i3.100
Published online Aug 28, 2013. doi: 10.5319/wjo.v3.i3.100
Adenosine amine congener ameliorates cisplatin-induced hearing loss
Niliksha Gunewardene, Cindy X Guo, Ann CY Wong, Department of Physiology, the University of Auckland, Auckland 1010, New Zealand
Niliksha Gunewardene, Department of Otolaryngology, the University of Melbourne, Melbourne, Parkville VIC 3010, Australia
Ann CY Wong, Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Peter R Thorne, Srdjan M Vlajkovic, Department of Physiology, Section of Audiology, and Centre for Brain Research, Faculty of Medical and Health Sciences, the University of Auckland, Auckland 1010, New Zealand
Author contributions: Vlajkovic SM and Thorne PR designed the study; Gunewardene N, Guo CX and Wong ACY performed research; Gunewardene N and Vlajkovic SM analysed data and wrote the paper; Thorne PR revised the paper
Supported by Action on Hearing Loss (United Kingdom)
Correspondence to: Dr. Srdjan M Vlajkovic, MD, PhD, Department of Physiology, Section of Audiology, and Centre for Brain Research, Faculty of Medical and Health Sciences, the University of Auckland, Private Bag 92019, Auckland 1010, New Zealand. s.vlajkovic@auckland.ac.nz
Telephone: +64-9-3737599 Fax: +64-9-3737499
Received: May 17, 2013
Revised: June 27, 2013
Accepted: July 23, 2013
Published online: August 28, 2013
Revised: June 27, 2013
Accepted: July 23, 2013
Published online: August 28, 2013
Core Tip
Core tip: This study investigated a novel pharmacological intervention to mitigate cisplatin ototoxicity using systemic administration of a selective adenosine A1 receptor agonist adenosine amine congener (ADAC). Our study demonstrates that systemic administration of ADAC confers partial protection from cisplatin-induced ototoxicity. In rats exposed to cisplatin, ADAC ameliorated high frequency hearing loss, improved the survival of the outer hair cells and reduced apoptosis of the outer hair cells and marginal cells in the stria vascularis. This study provides support for the otoprotective role of ADAC with potential clinical benefits extending from noise-induced hearing loss to cisplatin ototoxicity.