Systematic Reviews
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Ophthalmol. May 12, 2015; 5(2): 86-98
Published online May 12, 2015. doi: 10.5318/wjo.v5.i2.86
Systematic review of macular ganglion cell complex analysis using spectral domain optical coherence tomography for glaucoma assessment
Amit Meshi, Dafna Goldenberg, Sharon Armarnik, Ori Segal, Noa Geffen
Amit Meshi, Sharon Armarnik, Ori Segal, Noa Geffen, Department of Ophthalmology, Meir Medical Center, Kfar Saba 4428164, Israel
Amit Meshi, Sharon Armarnik, Ori Segal, Noa Geffen, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel
Dafna Goldenberg, Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel
Author contributions: Meshi A and Geffen N contributed equally to this work; each one substantially contributed to study design and to writing, to acquisition, analysis and interpretation of the data and performed critical revisions; Goldenberg D participated in the acquisition of the data and in writing, contributed significantly to the analysis of the technical data and performed critical revisions; Armarnik S participated in the acquisition of the data, in writing and approved the final version of the article to be published; Segal O performed critical revision and participated in the acquisition of the data; all authors approved the final version of the article.
Conflict-of-interest: All authors have no conflict of interest related to this work.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Noa Geffen, MD, Glaucoma Consultant, Department of Ophthalmology, Meir Medical Center, 59 Tschernihovsky St., Kfar Saba 4428164, Israel. noatal1122@gmail.com
Telephone: +972-54-2211710 Fax: +972-77-5610362
Received: August 15, 2014
Peer-review started: August 17, 2014
First decision: October 14, 2014
Revised: February 9, 2015
Accepted: April 1, 2015
Article in press: April 7, 2015
Published online: May 12, 2015
Core Tip

Core tip: Glaucoma is an optic neuropathy characterized by structural changes followed by functional deficits. Diagnosing early signs of the disease and detecting its progression are challenging. This review focuses on the most common macular retinal ganglion cells/ganglion cell complex spectral domain optical coherence tomography (SD-OCT) scanning strategies developed for glaucoma assessment (Cirrus high definition-OCT, RTVue, Spectralis and 3D OCT 2000) described in the literature published through July 2014; specifically, studies that assessed the ability to diagnose early glaucoma and glaucoma progression. The findings highlight the central role of macular SD-OCT in identifying subjects with early and progressive anatomical and functional glaucomatous damage.