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World J Ophthalmol. Nov 12, 2014; 4(4): 113-123
Published online Nov 12, 2014. doi: 10.5318/wjo.v4.i4.113
What is new in central serous chorioretinopathy?
Michal Schaap-Fogler, Rita Ehrlich
Michal Schaap-Fogler, Rita Ehrlich, Department of Ophthalmology, Rabin Medical Center, Petach Tikva 49100, Israel
Author contributions: Schaap-Fogler M and Ehrlich R both contributed to this paper, including: (1) substantial contributions to conception and design, acquisition of data and interpretation of data; (2) drafting the article and revising it critically for important intellectual content; and (3) final approval of the version to be published.
Correspondence to: Michal Schaap-Fogler, MD, Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, 39 Zabotinski Street, Petach Tikva 49100, Israel.
Telephone: +972-39-376107 Fax: +972-39-376104
Received: May 29, 2014
Revised: July 5, 2014
Accepted: September 4, 2014
Published online: November 12, 2014

Central serous chorioretinopathy (CSCR) is considered a benign, self-limiting disease. However, as many as third of the patients have recurrent episodes or chronic disease that may cause significant functional impairment. New diagnostic tools and new treatment modalities are emerging in order to improve the functional outcomes of these patients. Spectral domain optical coherence tomography (SD-OCT) has the ability to image individual layers of the retina and choroid. SD-OCT images in CSCR patients have demonstrated increased subfoveal thickness measurements, high reflective deposits in areas of subretinal precipitates and changes in the Retinal pigment epithelium layers of the asymptomatic eyes of patients with supposedly unilateral CSCR. A positive correlation was found between the level of distribution to the layer of inner segment/outer segment junction of the photoreceptors and the visual impairment. Fundus autoflouresence images show a wide variety during different stages of the disease in CSCR patients. Minimal abnormalities during the early stages are followed by hyperautofluoresence in the detached area in later stages, often in a manner of inferior gravitation and at the borders of the detachments. The chronic phase is characterized by varying degrees of atrophy and areas of decreased autofluorescence surrounding areas of chronic leaks. These changes help differentiate an active disease from an inactive state. Multifocal electroretinography (mfERG) has the ability to demonstrate a persistent depression despite the resolution of subretinal detachments. It is therefore being investigated as a follow up tool for patients with chronic CSCR. An excellent correlation was found between changes in mfERG and visual function. Macular microperimetry, measuring retinal sensitivity within the central visual field, is intended to compensate for the underestimation of visual impairment in patients with macular diseases. Reduced retinal sensitivity was found in areas of previous subretinal fluids in CSCR patients. The device can also serve as a follow up tool in these patients. Regarding treatment in CSCR patients, focal argon laser photocoagulation treatment may be applied to small extrafoveal leaks. However, the main purpose of this treatment is to shorten disease duration, with no advantage over observation regarding final visual outcome, rate of progression to chronic CSCR or number of recurrences. Photodynamic therapy (PDT) with verteporfin has been shown to completely resolve serous detachment in 60%-80% of patients and to have a partial affect in the remaining patients. Reduced-fluence treatment is replacing full-fluence therapy in order to minimize side effects with no accompanying reduced effectiveness. Visual acuity is also improved following reduced-fluence PDT compared to placebo. It has also been found that patients with intense hyperfluorescence are more likely to show resolution of accumulating fluid compared to patients with mild or no leakage observed on indocyanine-green angiography prior to treatment. Regarding newer treatment modalities, intravitreal injections of anti-vascular endothelial growth factor agents have a limited effect in patients with CSCR. Recent reports have not demonstrated an advantage for this treatment in regards to anatomic and functional outcome. Micropulse diode laser was not proven to be safer or more effective than argon laser or PDT. Corticosteroid antagonists, not tested in controlled trials, may have a beneficial effect in patients with CSCR. Aspirin may also play a role in treating these patients, with rapid recovery of visual acuity and reduced number of recurrences observed. In conclusion, imaging is evolving rapidly while the clinical implications of these new imaging modalities are less clear. Large randomized trials investigating different treatment modalities are still lacking.

Keywords: Central serous chorioretinopathy, Optical coherence tomography, Fundus autoflouresence, Multifocal electroretinography, Macular microperimetry

Core tip: (1) New diagnostic tools and therapies may improve the prognosis of patients with chronic or recurrent central serous chorioretinopathy; (2) Changes in fundus autoflouresence images help differentiate an active disease from an inactive state; (3) Multifocal electroretinography and macular microperimetry may serve as follow up tools due to their ability to measure macular visual function; (4) Focal argon laser photocoagulation shortens disease duration but does not affect final prognosis; (5) Reduced-fluence photodynamic therapy improves visual acuity and resolves serous detachments; and (6) The role of anti-vascular endothelial growth factor agents, micropulse diode laser, corticosteroid antagonists, aspirin, anti-viral or Helicobacter pylori treatment is still being investigated.