Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Neurol. Dec 28, 2013; 3(4): 133-137
Published online Dec 28, 2013. doi: 10.5316/wjn.v3.i4.133
Published online Dec 28, 2013. doi: 10.5316/wjn.v3.i4.133
Overview of botulinum toxin as a treatment for spasticity in stroke patients
Hirotaka Isoyama, Department of Physical Medicine and Rehabilitation, Hospital of Hokkaido University, Hokkaido 060-8648, Japan
Naoyuki Takeuchi, Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai 980-8576, Japan
Author contributions: Both authors contributed to the manuscript.
Correspondence to: Hirotaka Isoyama, MD, Department of Physical Medicine and Rehabilitation, Hospital of Hokkaido University, Kita14 Nishi5 Kita-ku, Sapporo, Hokkaido 060-8648, Japan. isoyama@huhp.hokudai.ac.jp
Telephone: +81-11-7066066 Fax: +81-11-7066067
Received: June 26, 2013
Revised: October 3, 2013
Accepted: November 2, 2013
Published online: December 28, 2013
Revised: October 3, 2013
Accepted: November 2, 2013
Published online: December 28, 2013
Core Tip
Core tip: In this overview, we describe that botulinum toxins (BTXs) were very useful to reduce spasticity in stroke patients. Moreover, we introduce studies on appropriate effective and safe injection methods; pilot studies that evaluated combined rehabilitation and BTX treatment; and adverse events after BTX injection, including risk factors of neutralizing antibodies.