Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.93
Revised: February 15, 2014
Accepted: June 18, 2014
Published online: August 6, 2014
Core tip: The mouse gene transducin β-like 3 (Tbl3) encodes a protein with thirteen WD40 protein-protein interaction motifs and is the mammalian homologue of yeast utp13. Virtually nothing is known about the function of tbl3. In this report, we provide the first direct evidence that Tbl3 is targeted to the nucleoli and plays an important role in regulating the synthesis of the 47S pre-ribosomal RNA, i.e., at very early stages of ribosome biogenesis. This activity has never been described before and sets Tbl3 apart from all other known nucleolar proteins. TBL3 may provide an attractive target for anti-neoplastic therapy.