Published online Aug 6, 2014. doi: 10.5315/wjh.v3.i3.115
Revised: February 8, 2014
Accepted: July 12, 2014
Published online: August 6, 2014
Core tip: Cytogenetic abnormalities are the hallmark of leukemias. We report here two cases of unusual cytogenetic abnormalities associated with Philadelphia chromosome, one with mixed phenotypic acute leukemia showing monosomy 7 and t(9;22) (q34;q11.2) and the other with chronic myeloid leukemia and additional translocation involving chromosomes 10 and 13. Both patients achieved complete remission following imatinib based treatment.These two cases highlight the novel additional cytogenetic abnormalities associated with Ph chromosome.