Primary cutaneous B cell lymphoma: Clinical features, diagnosis and treatment

Table 1 World Health Organization and European Organization of Research and Treatment of Cancer classification of primary cutaneous B cell lymphoma (2005)

Primary cutaneous B cell Lymphoma

Primary cutaneous marginal zone B cell lymphoma

Primary cutaneous follicle center lymphoma

Primary cutaneous diffuse large B cell lymphoma, leg type

Primary cutaneous diffuse large B cell lymphoma, other

Intravascular large B cell lymphoma

Table 2 International Society for Cutaneous Lymphomas and European organization of Research and treatment of cancer TNM classification staging for cutaneous lymphomas other than mycosis fungoides and Sezary syndrome

T

T1: Solitary skin involvement

T1a: A solitary lesion less than 5 cm diameter

T1b: A solitary lesion greater than 5 cm diameter

T2: Regional skin involvement

T2a: All disease in a 15-cm-diameter circular area

T2b: All disease in a 15 and 30 cm diameter circular area

T2c: All disease in a 30-cm-diameter circular area

T3: Generalized skin involvement

T3a: Multiple lesions involving 2 noncontiguous body regions

T3b: Multiple lesions involving 3 or more body regions

N

N1: Involvement of 1 peripheral lymph node region that drains an area of current or prior skin involvement

N2: Involvement of 2 or more peripheral lymph node regions or involvement of any lymph node region that does not drain an area of current or prior skin involvement

N3: Involvement of central lymph nodes

M

M0: No evidence of extra-cutaneous disease (other than lymph node)

M1: Extracutaneous disease is present (other than lymph node)

T: Tumor; N: Lymph node; M: Metastasis.