Published online Feb 2, 2015. doi: 10.5314/wjd.v4.i1.50
Peer-review started: October 3, 2014
First decision: November 27, 2014
Revised: December 18, 2014
Accepted: January 9, 2015
Article in press: Janurary 12, 2015
Published online: February 2, 2015
Core tip: Primary cutaneous B cell lymphoma is a type of lymphoma that presents in the skin without evidence of extra-cutaneous involvement. Prognosis and treatment being different from systemic lymphomas involving the skin makes differential diagnosis very important. It is a heterogeneous group of diseases that consists of indolent (primary cutaneous marginal zone lymphoma, primary cutaneous follicle centre lymphoma) and aggressive forms (primary cutaneous diffuse large B cell lymphoma, leg type and intravascular large B cell lymphoma). The indolent forms are mostly confined to the skin and have good prognosis whereas aggressive forms present with disseminated disease and are treated mostly with systemic combination chemotherapies.