Nicolau syndrome: A literature review

Table 2 Drug list related to nicolau syndrome

Drug	Target disease or symptom of using drug	Ref.	Duration of necrosis	Affected site
Naltrexone	Alcohol dependency	Perli et al[25]	Over 7 d	Buttock
Etanercept	Psoriatic arthritis	Guarneri et al[21]	10 d	Abdomen
Ketorolac	NS	Marangi et al[26]	2 wk	Buttock
Ketoprofen	Knee pain	Kim et al[27]	NS	Buttock
	COM	Lee et al[28]
Meperidine	Operation site pain	Kim et al[27]		Buttock
Gentamycin	Elbow sprain	Kim et al[29]		Buttock
Chlorpheniramine maleate	Pruritus	Nischal et al[30]	7 d	Arm
Trabit	Back pain	Ruffieux et al[31]		Buttock
Triamcinolone acetonide	Lichen planus of scalp	Ruffieux et al[31]		Buttock
Salicylate bismuth	Syphilis	Corazza et al[2]	A few days	Buttock, thigh
Ibuprofen	Coxarthrosis	Corazza et al[2]		Buttock
Interferon β		Ozcan et al[5]	3 d	Arm
Benzathine penicillin	Cellulitis	Ruffieux et al[31]		Buttock, L/Ext.
	NS	De Sousa et al[32]	1 d
		Ocak et al[23]
Penicillin G	Fever and cough	Luton et al[12]	2 d	Buttock, L/Ext.
Cyanocobalamin		Luton et al[12]		Buttock
Thiocolchicoside	Back pain	Guarneri et al[7]	2	Buttock
Glatiramer acetate	Multiple sclerosis	Harde et al[22]	2 d	Lower abdomen
		Koller et al[33]
Piroxicam	Ankle sprain	Lee et al[8]		Ankle
DPT	Vaccination	Erkek et al[15]	2 wk	Thigh
DTP-polio-Hib	Vaccination	Bégin et al[14]	2 wk	Thigh
Hydroxyzine	Itching	Gayken et al[16]		Thigh
Calcium hydroxide	Bleeding in the distal root canal	Willbrand et al[34]		Cheek
Lidocaine	Core needle biopsy on breast	García-Vilanova-Comas et al[20]		Breast
Vitamin K	Prematurity	Puvabanditsin et al[18]	2 wk	Thigh
Mesotherapy injections	Tendinopathy	Zaragoza et al[35]	3 wk	Knee

NS: Non-specific; COM: Chronic otitis media; Trabit: Phenylbutazone, salicylamide, dexamethasone and lidocaine; L/Ext: Lower extremity; DPT: Diphtheria-tetanus-pertussis.