Published online Nov 2, 2015. doi: 10.5314/wjd.v4.i4.135
Peer-review started: June 23, 2014
First decision: August 14, 2014
Revised: June 24, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: November 2, 2015
Core tip: Mycosis fungoides, the most common cutaneous lymphoma, may imitate diverse diagnoses both on clinical and on histological grounds. Hence, the former “great masquerader” syphilis may be regarded as being outpaced. As diagnosis of such ambiguous, atypical cases of mycosis fungoides may be a challenge for the dermatologist and pathologist and consecutively adequate therapeutic measures may be delayed we herein give a comprehensive overview on previously published cases accomplished by our own data. We conclude that a multi-step diagnostic algorithm including meticulous clinicopathological correlation together with molecular genetic analysis should be applied in such protean cases to obtain the correct diagnosis.