Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Dermatol. May 2, 2015; 4(2): 69-79
Published online May 2, 2015. doi: 10.5314/wjd.v4.i2.69
Mycosis fungoides and Sézary syndrome: Role of chemokines and chemokine receptors
Stephen Chu-Sung Hu
Stephen Chu-Sung Hu, Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Stephen Chu-Sung Hu, Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Author contributions: Hu SC performed the literature review and wrote the paper.
Conflict-of-interest: None declared.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Stephen Chu-Sung Hu, MBBS, M.Phil, Department of Dermatology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan. stephenhu30@hotmail.com
Telephone: +886-7-3121101 Fax: +886-7-3118894
Received: January 26, 2015
Peer-review started: January 28, 2015
First decision: March 6, 2015
Revised: March 16, 2015
Accepted: April 8, 2015
Article in press: April 9, 2015
Published online: May 2, 2015
Core Tip

Core tip: Mycosis fungoides and Sézary syndrome are characterized by a clonal expansion of malignant CD4+ T lymphocytes with skin-homing properties. Currently, treatment options for mycosis fungoides and Sézary syndrome are limited. The lack of effective targeted therapy results in part from the poor understanding regarding the pathophysiology of these diseases. Recently, a number of chemokines and chemokine receptors have been found to contribute to the pathogenesis of mycosis fungoides and Sézary syndrome, including the CC chemokine receptor 4 (CCR4)/chemokine (C-C motif) ligand 17 (CCL17), CCR10/CCL27, C-X-C chemokine receptor type 4/chemokine (C-X-C Motif) ligand 12 and CCR7/CCL21 axes. Therefore, these chemokines and chemokine receptors may be potentially useful targets for the treatment of these lymphomas in the future.