Published online Aug 2, 2014. doi: 10.5314/wjd.v3.i3.45
Revised: April 3, 2014
Accepted: July 12, 2014
Published online: August 2, 2014
Core tip: Contact dermatitis (CD) is the most common professional skin disease. CD is classified into irritant (ICD) and allergic (ACD), with both subtypes displaying sub-acute, acute and/or chronic eczema. The gold standard in CD diagnosis is patch-testing, although its validity and reproducibility are under question. Real-time reflectance confocal microscopy is a very promising tool for the diagnosis and management of ACD and ICD, providing significant advantage over conventional histology (due to the possibility to manage the disease through repetitive assessment) and patch-testing, due to increased sensitivity and specificity.