Systematic Reviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Dermatol. Feb 6, 2023; 11(2): 7-29
Published online Feb 6, 2023. doi: 10.5314/wjd.v11.i2.7
Systematic review of hematidrosis: Time for clinicians to recognize this entity
Gilbert Sterling Octavius, Fellisa Meliani, Rivaldo Steven Heriyanto, Theo Audi Yanto
Gilbert Sterling Octavius, Fellisa Meliani, Rivaldo Steven Heriyanto, Theo Audi Yanto, Department of Medicine, Universitas Pelita Harapan, Tangerang 15811, Indonesia
Author contributions: Octavius GS and Yanto TA did the conception of this research; Data collections and selections are done by Octavius GS, Heriyanto RS, and Meliani F; Octavius GS, Heriyanto RS, and Meliani F drafted the article while Yanto TA did critical revision of the article; Final approval of the version to be published was granted by all authors.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Gilbert Sterling Octavius, MD, MM, Doctor, Researcher, Department of Medicine, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Klp. Dua, Kec. Klp. Dua, Kota Tangerang, Banten, Tangerang 15811, Indonesia.
Received: August 22, 2022
Peer-review started: August 22, 2022
First decision: September 27, 2022
Revised: October 12, 2022
Accepted: November 29, 2022
Article in press: November 29, 2022
Published online: February 6, 2023
Research background

Hematidrosis is a largely unknown entity, even to professional doctors.

Research motivation

In order to bridge the underlying knowledge deficit about hematidrosis, an updated systematic review is conducted.

Research objectives

We aim to conduct a systematic review of hematidrosis and identify the clinical characteristics, laboratory findings, as well as treatments given so far.

Research methods

We conducted a systematic search on eight different databases with no restrictions on the timeline using the English language.

Research results

There are 74 articles with 106 hematidrosis cases with India and China contributing the most cases. Patients are mostly females aged around 13 years. Bleeding occur most in the head region while beta-blockers and anxiolytics are the most frequent treatment given.

Research conclusions

Hematidrosis exists, and it is up to clinical researchers to further dissect this entity so that physicians can give better treatment in the future.

Research perspectives

More controlled skin biopsies and genetic studies with prospective follow-up or case-control studies may be needed to elucidate further and deepen our understanding of the pathophysiology and treatment of this disease.