Case Report
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Dermatol. Aug 2, 2016; 5(3): 125-128
Published online Aug 2, 2016. doi: 10.5314/wjd.v5.i3.125
Local hyperthermia cleared multiple cutaneous warts on a nephrotic syndrome patient
Yu-Jing Zhang, Rui-Qun Qi, Xing-Hua Gao
Yu-Jing Zhang, Rui-Qun Qi, Xing-Hua Gao, Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Zhang YJ performed the treatment and wrote the report; Qi RQ and Gao XH designed the report.
Institutional review board statement: This study was reviewed and approved by the China Medical University Institutional Review Board.
Informed consent statement: The patient involved in the study gave her consent authorizing use and disclosure of her protected health information.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Xing-Hua Gao, MD, PhD, Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing St, Heping District, Shenyang 110001, Liaoning Province, China.
Telephone: +86-24-83282326 Fax: +86-24-83282633
Received: February 16, 2016
Peer-review started: February 16, 2016
First decision: March 1, 2016
Revised: March 15, 2016
Accepted: May 10, 2016
Article in press: May 11, 2016
Published online: August 2, 2016

Cutaneous warts are caused by human papillomavirus infection. Immunosuppressive state is one of the risk factors of human papillomavirus infection. A girl diagnosed of nephrotic syndrome and on immunosuppressive therapy developed multiple common warts. We treated her on a single lesion by local hyperthermia therapy at 44 °C for 3 consecutive days, each therapy lasted for 30 min. Ten days later, the patient received another 2 consecutive therapy. All lesions are completely resolved at the 9th week after the treatment. No recurrent sign was observed in a 3-mo follow-up. Side effects included burning sensation, stabbing pain at the target site during treatment.

Keywords: Hyperthermia, Warts, Nephrotic syndrome, Immunosuppression

Core tip: Common warts on immunosuppressive patients are characterized by multiple lesions, long duration and hard to treat. Current treatment method includes laser therapy, cryotherapy, topical salicylic acid, etc. Scar formation and high recurrence rate are the most common disadvantages of these treatments. In this case report, we provide a noninvasive treatment method called hyperthermia treatment. Using this method we succeed to cure multiple warts on a nephrotic syndrome patient who received immunosuppressive treatment for years without any scar formation. And we did not see recurrence 3 mo after the treatment.