Published online Jul 27, 2014. doi: 10.5313/wja.v3.i2.162
Revised: May 22, 2014
Accepted: June 10, 2014
Published online: July 27, 2014
Core tip: Lumbar radiculopathy is the most common form of neuropathic pain. However, the diagnosis of lumbar radiculopathy is still not satisfactory because of the largely unknown neurobiological basis of neuropathic pain and paresthesia. Accumulating evidence has shown that lumbar radiculopathy is a multi-factor disease and may involve almost all types of pain, including ischemic, inflammatory, mechanical, and neuropathic pain. Ion channels such as Acid-sensing ion channel 3, Piezo2 and transient receptor potential vanilloid receptor 1 responding to tissue acidosis, mechanical force, and inflammatory mediators may be the pathways transducing the pain.