Topic Highlight
Copyright ©2013 Baishideng Publishing Group Co.
World J Orthop. Oct 18, 2013; 4(4): 207-217
Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.207
Table 1 Comparison of features between ovariectomy and GST-RANKL bone loss models
TechniqueOVX modelGST-RANKL bone loss model
TechniqueOVXIntraperitoneal injections
Term for establishment> 4 wk24-50 h
Term for evaluation of BP> 4 wk3 d
Term for evaluation of PTH> 4 wk14 d
Term for evaluation of SERM> 4 wk18 d
Term for evaluation of anti-human RANKLNo9 d
Term for evaluation of Tec tyrosine kinase inhibitor
NA50 h
Evaluation of male animalsNoYes
Term for pharmacological experimentsSeveral monSeveral wk/d
Advantages
Human disease modelRapid, easy, simple, and inducible model
Table 2 Comparison of serum soluble RANKL concentrations among various mouse models
Mouse modelsRANKL (ng/mL)Phenotype
Ad-sRANKL injection (High)1500Severe osteoporosis/hypercalcemia
Ad-sRANKL injection (Low)233Severe osteoporosis/hypercalcemia
sRANKL-Tg mice30Severe osteoporosis
GST-RANKL injection3.51Osteoporosis
Wild mice0.1Normal