Manfreda F, Bufi E, Florio EF, Ceccarini P, Rinonapoli G, Caraffa A, Antinolfi P. Osteolysis in total hip arthroplasty in relation to metal ion release: Comparison between monolithic prostheses and different modularities. World J Orthop 2021; 12(10): 768-780 [PMID: 34754833 DOI: 10.5312/wjo.v12.i10.768]
Corresponding Author of This Article
Francesco Manfreda, MD, Research Scientist, Surgeon, Department of Orthopedics and Traumatology, University of Perugia, Via G. Dottori, Perugia 06100, Italy. francesco.manfreda@libero.it
Research Domain of This Article
Orthopedics
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Oct 18, 2021; 12(10): 768-780 Published online Oct 18, 2021. doi: 10.5312/wjo.v12.i10.768
Table 1 Patients with monolithic total hip arthroplasty
Group A
Patient
Age
Cr serum (μg/L)
Cr urine (μg/L)
Co serum (μg/L)
Co urine (μg/L)
1
58
0.53
0.69
3.9
6
2
63
0.14
0
0
0.76
3
69
0.92
2.71
3.22
14.53
4
76
0.8
2.14
11.1
34.9
5
77
0.07
0.11
0.1
0.1
6
65
no
1.48
5.03
14.9
7
71
0.1
0.4
0.82
0.2
8
74
0.08
0.61
0.73
2.1
9
75
0.5
1.13
4.3
9.6
10
78
0.77
2.94
10.65
27.5
11
79
2.05
4.36
7.92
17.4
12
75
0.7
1.7
4.6
9.4
13
65
0.37
2.3
7.84
26
14
75
1.14
3.86
6.38
24.2
15
70
0.1
0.1
0.1
0.1
16
69
0.3
1.25
1.77
7.1
17
72
0.34
0.04
0.1
0
18
71
0.76
1.07
2.06
9.3
19
74
0.1
0.09
0.67
0.1
20
65
0.1
0.22
1.34
3.9
21
64
0.1
0.52
0.34
0.2
22
72
1.87
3.69
7.25
12.38
23
78
0.1
1.02
2.41
10.7
Mean
71.08
0.54
1.41
3.59
10.06
ST.DEV
0.56
1.33
3.46
10.19
Table 2 Patients with modular/ceramic head total hip harthroplasty
Group B
Patient
Age
Cr serum (μg/L)
Cr urine (μg/L)
Co serum (μg/L)
Co urine (μg/L)
24
68
1.56
3.9
4.19
19.2
25
71
0.1
2.34
2.09
21.15
26
69
0.38
1.59
2.3
15.2
27
70
0.67
1.91
0.61
0.2
28
71
2.25
7.52
5.6
17.7
29
75
0.77
2.36
6.33
19.5
30
55
0.44
1.55
3.76
19.9
31
74
0.53
1.9
3.4
23.9
32
76
0.55
1.94
2.95
29.4
33
74
0.18
0.24
1.83
4.7
34
69
0.11
1.54
0.85
0.2
35
81
0.2
1.28
1.79
2.1
36
78
0.5
0.49
3.93
12.5
37
65
0.38
3.89
1.44
12.4
38
74
1.03
2.59
6.28
26.4
39
79
0.73
3.19
2.55
4.7
40
72
0.35
1.57
1.93
16
41
73
0.24
0.78
2.19
5.3
42
55
1.13
1.97
1.93
7.2
43
71
0.1
1.41
0.46
27.2
44
77
1.96
3.48
3.63
24.4
Mean
71.28
0.67
2.34
3.05
14.42
ST.DEV
0.60
1.66
1.76
9.18
Table 3 Patients with modular/metallic head total hip arthroplasty
Group C
Patient
Age
Cr serum (μg/L)
Cr urine (μg/L)
Co serum (μg/L)
Co urine (μg/L)
45
84
1.78
4
7.02
27.7
46
73
0.9
4.89
9.8
28.9
47
67
2.19
8.4
5.1
19.1
48
73
0.27
2.56
4.43
24.9
49
69
1.26
5.04
8.56
40.1
50
68
0.26
0.8
3.01
15
51
73
0.32
3.18
3.2
18.2
52
74
0.1
1.96
2.7
3.5
53
62
0.84
2.96
3.5
12.3
54
79
0.81
3.27
4.45
19.7
55
71
0.55
2.72
3.86
18.6
56
78
2.5
1.9
5.22
14.8
57
73
0.84
1.99
0.46
7.5
58
59
1.31
3.8
4.77
25.3
59
75
0.19
2.99
4.03
22.5
60
59
0.39
0.88
0.76
7.89
61
74
0.9
3.5
4.56
24.7
62
52
0.55
0.98
5.55
19.8
63
64
0.7
2.21
4
14.5
64
85
0.59
7.19
5.72
41.6
65
72
1.94
4.69
7.14
41.9
66
77
0.15
1.94
2.17
16.1
67
71
0.1
1.58
1.33
7.9
68
72
1.4
3.57
8.84
35.4
69
85
1.24
2.07
13.78
60.2
70
32
2.65
1.77
7.03
16.7
71
79
1.27
3.28
2.09
18.2
72
79
0.84
1.7
4.52
17
73
74
0.96
3.89
15.47
36.8
74
60
0.14
1.05
4.94
11.16
75
79
0.49
2.41
1
6
76
78
0.75
1.5
7.22
18
Mean
70.93
0.91
2.95
5.29
21.73
ST.DEV
0.69
1.75
3.41
12.64
Table 4 Localization of osteolysis in peri-prosthetic field
Group A
Group B
Group C
Site of osteolysis
Gruen zone 7
2
2
4
Gruen zone 1
2
6
12
DeLee zone 1 and 2
5
3
3
Table 5 For every group mean values of blood and urinal concentration of Chrom and Cobalt are related to cases of osteolysis
Cr Serum (μg/L)
Cr urine (μg/L)
Co serum (μg/L)
Co urine (μg/L)
Cases of Gr. 2 osteolysis
Cases of Gr. 3 osteolysis
Group 1
0.54
1.41
3.59
10.06
2
0
Group 2
0.67
2.24
3.05
14.42
7
0
Group 3
0.91
2.95
5.29
21.73
9
3
Citation: Manfreda F, Bufi E, Florio EF, Ceccarini P, Rinonapoli G, Caraffa A, Antinolfi P. Osteolysis in total hip arthroplasty in relation to metal ion release: Comparison between monolithic prostheses and different modularities. World J Orthop 2021; 12(10): 768-780