Current and future medical therapeutic strategies for the functional repair of spinal cord injury

Figure 1 Major mechanisms of cell death are ischemia, intracellular calcium deposition, apoptosis. Pharmacological agents may intervene in these mechanisms at different stages shown in boxes (From Dumont RJ).

Figure 2 Role of vascular effects, inflammation, interstitial edema, glutamate release, cord compression and reperfusion which underlie the spinal cord injury are shown. Pharmacological agents may be useful at foci which are demonstrated in boxes (From Dumont RJ).