Prospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2017; 8(9): 719-725
Published online Sep 18, 2017. doi: 10.5312/wjo.v8.i9.719
Association of adiponectin gene polymorphisms with knee osteoarthritis
Dong Zhan, Suthimon Thumtecho, Aree Tanavalee, Pongsak Yuktanandana, Wilai Anomasiri, Sittisak Honsawek
Dong Zhan, Wilai Anomasiri, Sittisak Honsawek, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
Suthimon Thumtecho, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
Aree Tanavalee, Pongsak Yuktanandana, Sittisak Honsawek, Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand
Author contributions: Zhan D, Anomasiri W and Honsawek S designed research; Tanavalee A and Yuktanandana P treated patients and collected samples and clinical data from patients; Zhan D and Thumtecho S performed the assays; Zhan D and Honsawek S analysed data; Zhan D and Honsawek S wrote the manuscript and revised the manuscript for final submission.
Institutional review board statement: This study was approved by the Institutional Review Board on Human Research of the Faculty of Medicine, Chulalongkorn University.
Informed consent statement: All study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at sittisak.h@chula.ac.th. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sittisak Honsawek, Professor, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Rd, Patumwan, Bangkok 10330, Thailand. sittisak.h@chula.ac.th
Telephone: +66-22-2564482 Fax: +66-22-2564482
Received: January 30, 2017
Peer-review started: February 12, 2017
First decision: March 28, 2017
Revised: April 19, 2017
Accepted: May 12, 2017
Article in press: May 13, 2017
Published online: September 18, 2017
Core Tip

Core tip: Plasma adiponectin levels were significantly lower in knee osteoarthritis (OA) than controls. No significant associations were observed in the genotype distributions and allele frequencies of ADIPOQ +45T/G and +276G/T polymorphisms between knee OA subjects and controls. There was a significant association between genotype distribution of +276G/T polymorphism and OA severity. In addition, plasma adiponectin in OA subjects was seemingly lower than that in control subjects in GG genotype of +45T/G and +276G/T polymorphisms. Polymorphisms +45T/G and +276G/T of the ADIPOQ gene might not be responsible for the susceptibility to knee OA in the Thai population.