Published online Jun 18, 2017. doi: 10.5312/wjo.v8.i6.491
Peer-review started: February 2, 2017
First decision: March 28, 2017
Revised: April 5, 2017
Accepted: May 3, 2017
Article in press: May 15, 2017
Published online: June 18, 2017
Core tip: With the widespread use of orthobiologics in everyday practice, attention must be directed to substantiate the evidence for their current use and to direct future practice guidelines. The use of concentrated bone marrow aspirate (cBMA) has become an increasingly popular alternative and adjunct in the treatment of cartilaginous lesions, bony defects, and tendinous injuries. This systematic review demonstrates the potential benefits of utilizing cBMA for the repair of different tissue types in the clinical setting. This systematic review also highlights discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, variable methods of application of cBMA, and the lack of standardized outcome measures.