RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening
Max J Friedrich, Matthias D Wimmer, Jan Schmolders, Andreas C Strauss, Milena M Ploeger, Hendrik Kohlhof, Dieter C Wirtz, Sascha Gravius, Thomas M Randau, Department of Orthopedics and Trauma Surgery, University Clinic of Bonn, 53125 Bonn, Germany
Author contributions: Friedrich MJ, Gravius S and Randau TM conceived and designed the research; Friedrich MJ, Wimmer MD, Ploeger MM, Kohlhof H, Strauss AC, Gravius S and Randau TM performed the experiments; Friedrich MJ, Randau TM, Schmolders J, Kohlhof H and Gravius S contributed to patient recruitment and data collection; Randau TM, Friedrich MJ, Wimmer MD, Strauss AC, Kohlhof H, Schmolders J, Ploeger MM and Gravius S analyzed the data; Randau TM, Friedrich MJ, Wimmer MD, Strauss AC, Schmolders J, Ploeger MM, Kohlhof H, Wirtz DC and Gravius S wrote the paper.
Supported by The “Deutsche Arthrose-Hilfe e.V.”, No. P192-A362-2009-12.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the University of Bonn (No. 046/09).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Not declared.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Thomas M Randau, MD, Department of Orthopedics and Trauma Surgery, University Clinic of Bonn, Sigmund Freud Str. 25, 53125 Bonn, Germany. email@example.com
Telephone: +49-228-28714460 Fax: +49-228-28715130
Received: October 12, 2016
Peer-review started: October 17, 2016
First decision: December 15, 2016
Revised: January 10, 2017
Accepted: February 8, 2017
Article in press: February 13, 2017
Published online: April 18, 2017