Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Challenges of bone tissue engineering in orthopaedic patients
Enrique Guerado, Department of Orthopaedic Surgery and Traumatology, Hospital Costa del Sol, University of Malaga, 29603 Marbella (Malaga), Spain
Enrique Caso, Research Unit, Hospital Costa del Sol, University of Malaga, 29603 Marbella (Malaga), Spain
Author contributions: Guerado E was the main author of the Introduction and the sections on RIA, the Masquelet technique and bone transportation; Caso E wrote the sections on combined stem cells therapy, tissue engineering and future directions; both authors jointly reviewed, corrected and edited the paper.
Conflict-of-interest statement: There is no conflict of interest to declare that could provoke any potential bias in the study design, the interpretation of the results obtained or the presentation of the scientific/medical content, including but not limited to commercial, personal, political, intellectual or religious interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Enrique Guerado, Professor and Chairman, Department of Orthopaedic Surgery and Traumatology, Hospital Costa del Sol, University of Malaga, Autovia A-7, Km 187, 29603 Marbella (Malaga), Spain. eguerado@hcs.es
Telephone: +34-951-976224
Received: September 14, 2016
Peer-review started: September 19, 2016
First decision: October 21, 2016
Revised: October 31, 2016
Accepted: November 21, 2016
Article in press: November 23, 2016
Published online: February 18, 2017
Peer-review started: September 19, 2016
First decision: October 21, 2016
Revised: October 31, 2016
Accepted: November 21, 2016
Article in press: November 23, 2016
Published online: February 18, 2017
Core Tip
Core tip: This paper discusses the problems created by large bone loss, especially after major trauma, and considers current alternatives to autograft or allograft, such as the reamer-irrigator-aspirator system, the Masquelet technique, bone transportation, or the combination of stem cell therapy and tissue engineering. Future Directions addressed mainly concern the new concepts of personalised medicine and precise medicine.