Published online Jan 18, 2017. doi: 10.5312/wjo.v8.i1.1
Peer-review started: July 26, 2016
First decision: September 6, 2016
Revised: September 19, 2016
Accepted: October 17, 2016
Article in press: October 18, 2016
Published online: January 18, 2017
Core tip: In this review we present and critically evaluate the current information regarding the administration of glucosamine (GL) and chondroitin (CH) for the treatment of knee or hip osteoarthritis. A clinical and radiological effect of GL and CH has been shown. However, only a few high quality trials exist. The effect sizes are small and probably not clinically relevant. The validity of these results is limited by high risk of bias introduced in the studies. Both GL and CH seem to be safe with no serious adverse events but there is currently no convincing information for their efficacy as treatment options in osteoarthritis.