Di Matteo B, Loibl M, Andriolo L, Filardo G, Zellner J, Koch M, Angele P. Biologic agents for anterior cruciate ligament healing: A systematic review. World J Orthop 2016; 7(9): 592-603 [PMID: 27672573 DOI: 10.5312/wjo.v7.i9.592]
Corresponding Author of This Article
Berardo Di Matteo, MD, I Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via Pupilli n. 1, 40136 Bologna, Italy. berardo.dimatteo@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Sep 18, 2016; 7(9): 592-603 Published online Sep 18, 2016. doi: 10.5312/wjo.v7.i9.592
Biologic agents for anterior cruciate ligament healing: A systematic review
Berardo Di Matteo, Markus Loibl, Luca Andriolo, Giuseppe Filardo, Johannes Zellner, Matthias Koch, Peter Angele
Berardo Di Matteo, Luca Andriolo, Giuseppe Filardo, I Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, 40136 Bologna, Italy
Markus Loibl, Johannes Zellner, Matthias Koch, Peter Angele, Department of Trauma Surgery, University Regensburg Medical Centre, 93042 Regensburg, Germany
Peter Angele, Sporthopaedicum Regensburg, 93053 Regensburg, Germany
Author contributions: Di Matteo B, Andriolo L, Filardo G and Koch M were responsible for the literature research and for collecting the data and preparing the figures and tables included in the manuscript; Di Matteo B, Loibl M, Zellner J and Angele P wrote the paper; Loibl M and Angele P were responsible for the critical revision of the entire manuscript.
Conflict-of-interest statement: No conflict of interest to declare for the present paper.
Data sharing statement: All the source data used to perform the present systematic review are available from the corresponding author at berardo.dimatteo@gmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Berardo Di Matteo, MD, I Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via Pupilli n. 1, 40136 Bologna, Italy. berardo.dimatteo@gmail.com
Telephone: +39-051-6366567 Fax: +39-051-583789
Received: April 20, 2016 Peer-review started: April 22, 2016 First decision: June 6, 2016 Revised: June 22, 2016 Accepted: July 14, 2016 Article in press: July 18, 2016 Published online: September 18, 2016
Core Tip
Core tip: There has been a growing interest in the past years on regenerative approaches to stimulate healing of musculo-skeletal tissues. The present systematic review focuses on the clinical application of biologic agents [platelet-rich plasma (PRP) and stem cells] to favor anterior cruciate ligament healing during procedures of reconstruction or repair. We show that there is inconclusive evidence to support the use of biologic augmentations, also due to the paucity of trials currently available, especially concerning stem cells. Looking at PRP, positive findings in terms of promotion of graft maturation were documented, but no beneficial influence was observed in terms of clinical outcome, bone-graft integration and prevention of tunnel enlargement.
