Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection
Jessica Amber Jennings, Karen E Beenken, Robert A Skinner, Daniel G Meeker, Mark S Smeltzer, Warren O Haggard, Karen S Troxel
Jessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States
Karen E Beenken, Daniel G Meeker, Mark S Smeltzer, Department of Microbiology and Immunology, University of Arkansas Medical Sciences, Little Rock, AR 72205, United States
Robert A Skinner, Jamesport, NY 11947, United States
Karen S Troxel, Zimmer Biomet, Warsaw, IN 46581, United States
Author contributions: Jennings JA planned and performed the majority of experiments and analyzed the data; Beenken KE and Smeltzer MS planned and assisted with animal experiments; Skinner RA and Meeker DG performed surgical procedures; Skinner RA assisted with histological analysis; Haggard WO and Troxel KS assisted with materials formulation and planning experiments.
Supported by Institutional support from Biomet, LLC.
Institutional animal care and use committee statement: Animal studies were approved by the Institutional Review Board at the University of Arkansas for Medical Sciences (IACUC protocol #3540) and followed the IACUC guidelines.
Conflict-of-interest statement: Studies were funded and by Biomet, LLC. Karen S Troxel, PhD, is an employee of Zimmer Biomet.
Data sharing statement: Technical appendix, statistical analysis, and dataset available from the corresponding author at jjnnings@memphis.edu.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jessica Amber Jennings, PhD, Assistant Professor, Department of Biomedical Engineering, University of Memphis, 330 Engineering Technology Building, Memphis, TN 38152, United States. jjnnings@memphis.edu
Telephone: +1-901-6782283 Fax: +1-901-6785281
Received: March 26, 2016
Peer-review started: March 27, 2016
First decision: May 13, 2016
Revised: May 23, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: August 18, 2016
