Rodriguez-Merchan EC, Valentino LA. Orthopedic disorders of the knee in hemophilia: A current concept review. World J Orthop 2016; 7(6): 370-375 [PMID: 27335812 DOI: 10.5312/wjo.v7.i6.370]
Corresponding Author of This Article
E Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana 261, 28046 Madrid, Spain. ecrmerchan@gmx.es
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Jun 18, 2016; 7(6): 370-375 Published online Jun 18, 2016. doi: 10.5312/wjo.v7.i6.370
Orthopedic disorders of the knee in hemophilia: A current concept review
E Carlos Rodriguez-Merchan, Leonard A Valentino
E Carlos Rodriguez-Merchan, Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, 28046 Madrid, Spain
Leonard A Valentino, Rush University Medical Center, Chicago, IL 60612, United States
Author contributions: Rodriguez-Merchan EC and Valentino LA wrote the article and reviewed the literature.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: E Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana 261, 28046 Madrid, Spain. ecrmerchan@gmx.es
Telephone: +34-91-5712871 Fax: +34-91-5712871
Received: January 8, 2016 Peer-review started: January 12, 2016 First decision: March 1, 2016 Revised: April 7, 2016 Accepted: April 21, 2016 Article in press: April 22, 2016 Published online: June 18, 2016
Core Tip
Core tip: Hemophilia is an inherited bleeding disorder due to deficiency of factor VIII (hemophilia A) or factor IX (hemophilia B) resulting in insufficient thrombin generation leading to recurrent intra-articular hemorrhages (hemarthroses). Prevention of hemarthroses with intravenous infusions of the deficient protein from infancy to adulthood (primary prophylaxis) should be considered to achieve optimal outcomes. If factor replacement therapy (FRT) is insufficient, or if patients are not adherent to the prescribed regimen, recurrent hemarthroses results in chondrocyte apoptosis (cartilage degeneration) and hypertrophy of the synovium (synovitis). Many surgical interventions are available for the knee joint. For example, to treat synovitis recalcitrant to FRT, there are two primary orthopedic modalities: Radiosynovectomy and arthroscopic synovectomy. This article reviews the pathogenesis, diagnosis and treatment of hemophilic arthropathy of the knee.
