Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Sep 18, 2015; 6(8): 623-628
Published online Sep 18, 2015. doi: 10.5312/wjo.v6.i8.623
Published online Sep 18, 2015. doi: 10.5312/wjo.v6.i8.623
Recent biological trends in management of fracture non-union
Khaled M Emara, Ramy Ahmed Diab, Department of Orthopaedic Surgery, Ain Shams University, Cairo 11511, Egypt
Ahmed Khaled Emara, Faculty of Medicine, Ain Shams University, Cairo 11511, Egypt
Author contributions: Emara KM designed and wrote up the research; Diab RA collected the data and wrote up the research; Emara AK collected the data and wrote up the research.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Khaled M Emara, Professor, Department of Orthopaedic Surgery, Ain Shams University, 13 B Kornish elNile, Agha Khan, Cairo 11511, Egypt. kmemara@hotmail.com
Telephone: +20-2-22055661 Fax: +20-2-22055662
Received: February 13, 2015
Peer-review started: February 13, 2015
First decision: May 13, 2015
Revised: May 31, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 18, 2015
Peer-review started: February 13, 2015
First decision: May 13, 2015
Revised: May 31, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 18, 2015
Core Tip
Core tip: Successful fracture healing requires mechanical stability and a viable biologic microenvironment. Fractures with compromised biology will benefit from treatment options that can augment the biologic potential at the site of bone repair. An ideal bone graft should be osteoinductive, osteoconductive, osteogenic, angiogenic and should provide mechanical support and promote physiologic healing without any significant adverse effects. Regenerative strategies like the use of bone morphogenic proteins, platelet rich plasma, stem cells and anabolic agents are promising in the treatment of fractures either acute or fracture non-union.