Published online Mar 18, 2015. doi: 10.5312/wjo.v6.i2.298
Peer-review started: February 8, 2014
First decision: April 4, 2014
Revised: August 15, 2014
Accepted: September 4, 2014
Article in press: September 10, 2014
Published online: March 18, 2015
Core tip: Osteoporosis is a well-known problem in patients with ankylosing spondylitis and other forms of spondyloarthritis. It may begin even in the early stages of the disease and inevitably causes vertebral fractures. Bone loss can be prevented with tumor necrosis factor blocking therapy by reducing inflammation at skeletal sites. Dual X-ray absorptiometry (DXA) is the preferred method to assess bone mass in the early stages of the disease or in patients without aberrant ossification of the spine. In advanced cases DXA measurements with lateral spinal projections or quantitative computed tomography may be referred.