Published online Mar 18, 2015. doi: 10.5312/wjo.v6.i2.221
Peer-review started: June 19, 2014
First decision: July 10, 2014
Revised: November 5, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: March 18, 2015
Core tip: High-resolution magnetic resonance imaging emerges as a useful tool for in vivo characterization of trabecular bone architecture (TBA). However, texture analysis is not frequently used as the large number of calculated parameters makes difficult their interpretation. Dealing with complexity and fractal properties of living beings, it is possible to quantify morpho-functional changes in aging and pathology with a limited number of parameters. In this context, fractal lacunarity appears the most suitable approach to TBA texture analysis as it describes discontinuity of bone network and sizes of bone marrow spaces, changes of which are an index of increased fracture risk.