Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Dec 18, 2015; 6(11): 961-969
Published online Dec 18, 2015. doi: 10.5312/wjo.v6.i11.961
Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model
Lorraine A Boakye, Keir A Ross, John M Pinski, Niall A Smyth, Amgad M Haleem, Charles P Hannon, Lisa A Fortier, John G Kennedy
Lorraine A Boakye, Keir A Ross, John M Pinski, Niall A Smyth, Amgad M Haleem, Charles P Hannon, John G Kennedy, Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY 10021, United States
Charles P Hannon, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, United States
Lisa A Fortier, Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States
Author contributions: Boakye LA was chief in creating the manuscript and running all pertinent experiments as well as documenting and analyzing the data; Ross KA was chief in the original animal surgeries, microscopic analysis and editing of the manuscript; Pinski JM assisted the experiments and contributed to editing of the manuscript; Smyth NA and Haleem AM helped to design the original animal model and were crucial in performing the original animal surgeries; additionally, Smyth NA was key to the designing pertinent modes of inquiry; Hannon CP contributed significantly to editing the manuscript; Fortier LA made significant contributions to the initial and subsequent literature reviews while providing edits to the manuscript; Kennedy JG provided primary mentorship regarding project design as well as edits to the manuscript.
Supported by Arteriocyte Inc.; the Ohnell Family Foundation; and Mr. and Mrs. Michael J Levitt.
Institutional review board statement: This study as approved by the Institutional Review Board of the Hospital for Special Surgery.
Institutional animal care and use committee statement: HSS Project # 09-11-03B; Date Approval Granted: 10/06/11.
Conflict-of-interest statement: None of the listed contributing authors have conflicts of interest with the exception of Fortier LA and Kennedy JG. Kennedy JG: Arteriocyte, Inc.: Paid consultant; Research support European Society for Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) Ankle and Foot Associates (AFAS): Board or committee member. Fortier LA: Arthrex, Inc.: Other financial or material support; Paid consultant Arthrex, Inc., Kensey nash Inc.: Research support Arthrex, Inc., Kensey Nash Inc.: Paid presenter or speaker International Cartilage Repair Society, International Veterinary Regenerative Medicine Society: Board or committee member Kensey Nash Inc.: Editorial or governing board.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Dryad repository, who will provide a permanent, citable and open-access home for the dataset.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: John G Kennedy, MD, FRCS, Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States.
Telephone: +1-646-7978880 Fax: +1-646-7978966
Received: April 10, 2015
Peer-review started: April 11, 2015
First decision: June 24, 2015
Revised: September 8, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: December 18, 2015
Core Tip

Core tip: Despite the prevalence of platelet rich plasma (PRP) in both practice and literature, there is a dearth of data exploring the specific factors crucial to its role as an adjunct to cartilage repair surgeries. Our results suggest that the increased expression pattern of transforming growth factor-beta1 in PRP-treated rabbit femoral condyles, compared to saline treated controls, is associated with enhanced cartilage repair at the graft-host interface following autologous osteochondral transplantation. Our results serve as an initial step in building a body of evidence behind the specific growth factors crucial to cartilage repair and promise to help us understand how formulations of PRP are effective in musculoskeletal healing.