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World J Orthop. Sep 18, 2014; 5(4): 486-495
Published online Sep 18, 2014. doi: 10.5312/wjo.v5.i4.486
Published online Sep 18, 2014. doi: 10.5312/wjo.v5.i4.486
Bone three-dimensional microstructural features of the common osteoporotic fracture sites
Huayue Chen, Department of Anatomy, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
Kin-ya Kubo, Seijoh University Graduate School of Health Care Studies, Aichi 476-8588, Japan
Author contributions: Chen H and Kubo KY contributed to this work.
Correspondence to: Huayue Chen, MD, PhD, Department of Anatomy, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. huayue@gifu-u.ac.jp
Telephone: +81-58-2306295 Fax: +81-58-2306298
Received: December 18, 2013
Revised: April 3, 2014
Accepted: May 31, 2014
Published online: September 18, 2014
Processing time: 245 Days and 11.6 Hours
Revised: April 3, 2014
Accepted: May 31, 2014
Published online: September 18, 2014
Processing time: 245 Days and 11.6 Hours
Core Tip
Core tip: The most common sites of the osteoporotic fractures include the vertebra, femoral neck and distal radius, where the microstructural information is a key for fully understanding osteoporosis pathogenesis and improving the prediction of fracture risk. Vertebral strength is mostly preserved by trabecular bone, which is microstructurally inhomogeneous, with lower bone volume in the central and anterior superior regions. Increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Distal radius shows significant variations in cortical porosity, which is the major element attributed to bone strength of the distal radius.