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World J Orthop. Jul 18, 2014; 5(3): 351-361
Published online Jul 18, 2014. doi: 10.5312/wjo.v5.i3.351
Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis
Egemen Ayhan, Hayrettin Kesmezacar, Isik Akgun
Egemen Ayhan, Department of Orthopaedics and Traumatology, Mersin University, Mersin 33110, Turkey
Hayrettin Kesmezacar, Isik Akgun, Kaktus Health Center, Istanbul 34394, Turkey
Author contributions: Ayhan E, Kesmezacar H and Akgun I contributed to this paper for conception and design, acquisition of data, and interpretation of data, drafting the article and revising it critically for important intellectual content, and final approval of the version to be published.
Correspondence to: Egemen Ayhan, MD, Department of Orthopaedics and Traumatology, Mersin University, Mersin 33110, Turkey.
Telephone: +90-532-6363693 Fax: +90-324-3374305
Received: December 29, 2013
Revised: March 9, 2014
Accepted: May 31, 2014
Published online: July 18, 2014
Core Tip

Core tip: Intraarticular (IA) corticosteroid injections can be considered as an adjunct to core treatment for short term reduction of moderate to severe pain in people with osteoarthritis (OA). IA hyaluronic acid (HA) injections might have efficacy and might provide pain reduction in mild OA of knee up to 24 wk. But for HA injections, the cost-effectiveness is an important concern that patients must be informed. Although more high-quality evidence is needed, recent studies indicate that IA platelet rich plasma injections are promising for relieving pain, improving knee function and quality of life, especially in younger patients, and in mild OA cases.