Tilkeridis K, Touzopoulos P, Ververidis A, Christodoulou S, Kazakos K, Drosos GI. Use of demineralized bone matrix in spinal fusion. World J Orthop 2014; 5(1): 30-37 [PMID: 24649412 DOI: 10.5312/wjo.v5.i1.30]
Corresponding Author of This Article
Georgios I Drosos, MD, PhD, Assistant Professor of Orthopaedics, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, Farm Nea Makri, 68100 Alexandroupolis, Greece. drosos@otenet.gr
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Konstantinos Tilkeridis, Athanasios Ververidis, Sotirios Christodoulou, Konstantinos Kazakos, Georgios I Drosos, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece
Panagiotis Touzopoulos, Department of Orthopaedic Surgery, General Hospital of Komotini, 69100 Komotini, Greece
Author contributions: Tilkeridis K, Touzopoulos P and Drosos GI contributed to conception and design of the study, acquisition, analysis and interpretation of data; Tilkeridis K, Touzopoulos P, Ververidis A and Christodoulou S contributed to drafting the article; Drosos GI, Ververidis A and Kazakos K contributed to revising the article; all the authors read and approved the final manuscript.
Correspondence to: Georgios I Drosos, MD, PhD, Assistant Professor of Orthopaedics, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, Farm Nea Makri, 68100 Alexandroupolis, Greece. drosos@otenet.gr
Telephone: +30-69-44380694 Fax: +30-25-51030339
Received: June 28, 2013 Revised: September 27, 2013 Accepted: November 1, 2013 Published online: January 18, 2014
Core Tip
Core tip: It is widely accepted that autologous iliac crest bone graft (ICBG) is considered the gold-standard for spinal fusion surgery, although it is associated with a series of complications and a morbidity rate. Demineralized bone matrix (DBM) could be successfully used as a potential graft extender, enhancer or substitute. Spinal surgeons can take advance of DBMs osteoinductivity and osteoconductivity and achieve good results in spinal fusion, with a significantly lower complication rate and results similar to these of ICBG. The most significant drawbacks to DBM may be the difference between and within products so, it is important the surgeon to remain updated of the product properties to optimize the successful use of DBM, and the fact that it is not useful as a structural graft material because of its amorphous consistency, so it has to be used in combination with other type of grafts or scaffolds increasing the cost.
