Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.229
Revised: August 5, 2013
Accepted: August 28, 2013
Published online: October 18, 2013
Core tip: Ruptured tendons heal poorly compared to skin, muscles and bones. Immobilization during repair has been shown to be detrimental for the healing process. Mechanical loading of the tendon callus gives rise to intracellular signaling, increases gene expression and protein synthesis. However, early loading reported clinical complications. A surgical technique based on control of the mechanical environment at the suture line provided satisfactory results. Therefore, understanding the interplay between loading and the healing process seems necessary. This review focuses on the biological processes that regulate tendon repair and timing of mechanical loading during the healing process. How do tendon cells sense mechanical forces?