Published online Oct 18, 2013. doi: 10.5312/wjo.v4.i4.167
Revised: June 7, 2013
Accepted: June 18, 2013
Published online: October 18, 2013
Core tip: Development of the spine and thoracic cage is a complex series of events involving multiple metabolic processes, genes and signaling pathways. During growth, complex phenomena follow a rapid succession. This succession of events, this establishment of elements, is programmed according to a hierarchy. Complex spinal deformities alter normal growth plate development and vertebral bodies become progressively distorted, perpetuating the disorder. Therefore, many scoliotic deformities can become growth plate disorders over time.