Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Aug 18, 2025; 16(8): 109149
Published online Aug 18, 2025. doi: 10.5312/wjo.v16.i8.109149
Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives
Ren-Xian Xie, Yi-Xuan Xing, Nian-Zhe Sun
Ren-Xian Xie, Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
Yi-Xuan Xing, Department of Emergency, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
Nian-Zhe Sun, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Nian-Zhe Sun, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Co-corresponding authors: Yi-Xuan Xing and Nian-Zhe Sun.
Author contributions: Xie RX contributed to this work as first author; Sun NZ, Xing YX and Xie RX designed the concept and outline and contributed to the writing and review of literature; Sun NZ was responsible for oversight and coordination; and all authors contributed to the editing of the manuscript. Prof. Xing YX served as co-corresponding author throughout this study, overseeing the design, validation, and manuscript drafting and reviewing. Prof. Sun NZ, co-corresponding author, directed project conceptualization and final editing. Both authors independently managed critical aspects: Prof. Xing YX led validation and analysis, while Pro. Sun NZ guided the research framework and integration. This distinction clarifies their complementary, non-overlapping responsibilities.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nian-Zhe Sun, MD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Received: May 6, 2025
Revised: June 13, 2025
Accepted: July 10, 2025
Published online: August 18, 2025
Processing time: 100 Days and 1.9 Hours
Core Tip

Core Tip: The integration of synthetic biomaterials, for example hydroxyapatite and β-tricalcium phosphate, with fibrin derivatives enhances bone regeneration by improving scaffold stability, cellular recruitment, and mechanical support. While promising, clinical adoption requires standardized protocols, long-term outcome validation, and personalized approaches to address complex bone defects in aging and comorbid populations.