Published online Mar 18, 2019. doi: 10.5312/wjo.v10.i3.123
Peer-review started: November 19, 2018
First decision: December 17, 2018
Revised: January 6, 2019
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: March 18, 2019
Core tip: Assessing patients with osteoporosis (OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation. Therapies to normalize gut microbiota in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant.