Published online Sep 18, 2023. doi: 10.5312/wjo.v14.i9.720
Peer-review started: July 6, 2023
First decision: August 4, 2023
Revised: August 15, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 18, 2023
The increasing incidence of osteoporosis and low bone mass, affecting a significant portion of individuals aged 50 years or older in China, underscores the urgent need to address this public health concern. While obesity's potential protective role and the complex interplay between body mass index (BMI), lipid profiles, and bone health are subjects of recent investigation, their specific impact on populations with osteoporosis and fragility fractures remains relatively unexplored.
The relationship between BMI, bone mass, and lipid profiles in populations with osteoporosis and fragility fractures remains understudied.
This study aims to shed light on the potential impact of weight gain and lipid profiles on bone health in individuals with fragility fractures which may provide a new method for the treatment of osteoporosis.
This retrospective study conducted at a single orthopaedic trauma center between January 2017 and December 2020 included participants aged 65 years and above with diagnosed fractures in specific region. Participants' comprehensive clinical data, including gender, age groups, BMI ranges, DXA scores, and laboratory measurements, were collected and analyzed using statistical software. Data were analyzed using IBM SPSS and GraphPad Prism software, employing t-tests, nonparametric tests, one-way ANOVA, multiple linear regression, and Pearson correlation tests (aP < 0.05, bP < 0.01, cP < 0.001, dP < 0.0001 denoting significance) after assessing normality with the Shapiro-Wilk test.
In this study involving 520 participants aged ≥ 65 years, distinct gender and age-related disparities were observed in osteoporosis prevalence and associated factors. While a significant divergence in age, sex, BMI, alkaline phosphatase (ALP), and triglyceride (TG) concentrations was noted among normal, osteopenic, and osteoporotic groups, multivariate analysis revealed age, sex, BMI, ALP, and TG concentrations as independent risk factors for osteoporosis. Differential correlations between BMI and bone health parameters, along with lipid profiles, were elucidated across age and gender cohorts. Notably, these findings underscore the intricate interplay between metabolic and skeletal factors in the context of osteoporosis.
In conclusion, osteoporotic patients showed significantly decreased BMI and TG levels in comparison with patients with normal bone mass in our study.
These results indicate an association between TG metabolism and bone metabolism and provide a new method for the treatment of osteoporosis.