Published online Mar 18, 2017. doi: 10.5312/wjo.v8.i3.278
Peer-review started: October 19, 2016
First decision: November 14, 2016
Revised: November 27, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: March 18, 2017
To investigate the correlations between clinical outcomes and biopsychological variables in female patients with knee osteoarthritis (OA).
Seventy-seven patients with symptomatic knee OA were enrolled in this study. We investigated the age, body mass index (BMI), pain catastrophizing scale (PCS) and radiographic severity of bilateral knees using a Kellgren-Lawrence (K-L) grading system of the subjects. Subsequently, a multiple linear regression was conducted to determine which variables best correlated with main outcomes of knee OA, which were pain severity, moving capacity by measuring timed-up-and-go test and Japanese Knee Osteoarthritis Measure (JKOM).
We found that the significant contributor to pain severity was PCS (β = 0.555) and BMI (β = 0.239), to moving capacity was K-L grade (β = 0.520) and to PCS (β = 0.313), and to a JKOM score was PCS (β = 0.485) and K-L grade (β = 0.421), respectively.
The results suggest that pain catastrophizing as well as biological factors were associated with clinical outcomes in female patients with knee OA, irrespective of radiographic severity.
Core tip: Plenty of previous studies have focused on biological factors such as aging, gender, body mass index, ethnicity and history of knee injury for knee pain in cases where there was a discordant relationship between radiographic severity and symptoms in knee osteoarthritis (OA). However, in the present study, we found that pain catastrophizing thought was highly associated with knee-related clinical outcomes, irrespective of radiographic severity, for female patients with knee OA, especially pain severity and quality of life.